1. damage or negatively affect something
crippling cost/effect, crippled the economy
As a verb, 'to cripple' means to deprive of the ability to function normally; and as a noun, 'a cripple' is an outdated and offensive term used to describe someone who is unable to walk normally due to a disability. As a verb, it is used in many professional contexts to describe severe effects: "The rise in inflation crippled the economy." "The damage to the machine had a crippling effect on our production." You could also be 'crippled' emotionally: "She was visibly crippled by the bad news."