Below is a list of points to give you an idea of what to look out for and also what Recruiters might look out for:

1. Is the Personal Profile relevant? The Personal Profile is a real chance to impress with relevant skills, experience and knowledge; and, if possible, adding a touch of personality. Does your CV come across like that or is it filled with meaningless clichés like 'I'm a good communicator' or 'I'm an extremely hard worker'. 
2. Is the Personal Profile passionate? Does your writing seem passionate about the role, the company and the industry itself? Have you done your research on the business? Have you come across enthusiastic?
3. Is the Personal Profile linked to the rest of your CV? In relation to the key skills mentioned in the Personal Profile...is there evidence of you using these skills time and time again? Have you backed up your claims?
4. Is your work history relevant? Do you have the right amount or level of experience? When it comes to work history, find the benchmark for what they're looking for. For example, "Ideal candidate will have 3 years' experience in a Senior Sales role". Ensure you are making cross-overs if you are lacking experience and make up for it with relevant qualifications (or vice versa).
5. Is your experience consistent? You should be able to explain gaps (if any) on your CV. If you don't have any explanation for gaps it could be a concern, and the recipient could flag it against you. They would also most likely question it if you made it to interview stage.
6. Have you given enough information/elaborated on important sections of the CV? If you've merely stated your work experience without explaining what you did or achieved in these positions, this is a missed opportunity. Explain exactly what you did in a professional manner. It could take some brainstorming sometimes, but when done right it can be brilliant.
7. Do all the dates add up? Did you ensure that all your dates are worked out correctly? Keep in mind that month dates are very helpful, but if it is not possible, it is extremely important (and necessary) to have year dates at the very least.
8. Do you have any other relevant courses/training related to the vacancy that might further your application? When someone first comes out of education, it can sometimes be difficult to get a job in the industry you want. Often the best, most committed candidates will have taken courses to improve their skills (outside of formal education or work). This is a big positive if you hold any that could relate.
9. Are your skills relevant to the role? Ensure that you have covered all bases with this one. Although impressive, if you have 'Pie-Eating Champion' or 'Javelin Throwing Expert', they are completely irrelevant unless they're the jobs you are going for. Again, steer clear of clichés like 'Good Communicator'. Instead, go for the necessities. If it's an Admin role, 'Expert/Proficient in Microsoft Office Suite' would be nice.
10. Can you prove it? The best CVs are filled with stats, percentages and examples to back up a candidate's claim. You could say, 'I made my employer lots of money', but having solid information like 'I made the Company 100k richer in six months using an e-mail campaign' (with further details) is much more reliable.
11. Is it well written? There are no excuses in today's world for spelling errors, typos or mistakes. With the help of a computer, you should be able to correct any of these mistakes if they're made. It is also very important that you structure your CV in a professional manner, especially if the position requires organisational skills. 

These are just a few points to reflect on when you have your CV completed. Get a fresh pair of eyes on it, too - preferably somebody whose opinion won't be biased. 

Best of luck with your application.